Arquivos de Asma, Alergia e Imunologia
https://www.aaai-asbai.org.br/article/doi/10.4322/2526-5393.26051242
Arquivos de Asma, Alergia e Imunologia
Letter to the Editor

Além da IgE: a emergência do MRGPRX2 como via de ativação mastocitária em reações imediatas a fármacos

Beyond lgE: the emergence of MRGPRX2 as a mediator of lmmediate reactions

Maurício Domingues Ferreira, Paulo Eduardo Silva Belluco

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References

1. Kolkhir P, Ali H, Babina M, Ebo D, Sabato V, Elst J et al. MRGPRX2 in drug allergy: what we know and what we do not know. J Allergy Clin Immunol. 2023;151(2):410-2. https://doi.org/10.1016/j.jaci.2022.09.004. PMid:36089079.

2. Baldo BA. MRGPRX2, drug pseudoallergies, inflammatory diseases, mechanisms, and distinguishing MRGPRX2‐ and IgE/FcεRI‐mediated events. Br J Clin Pharmacol. 2023;89(11):3232-46. https://doi.org/10.1111/bcp.15845. PMid:37430437.

3. McNeil BD, Pundir P, Meeker S, Han L, Undem BJ, Kulka M et al. Identification of a mast-cell-specific receptor crucial for pseudoallergic drug reactions. Nature. 2015;519(7542):237-41. https://doi.org/10.1038/nature14022. PMid:25517090. 

4. McNeil BD. Minireview: Mas-related G protein-coupled receptor X2 activation by therapeutic drugs. Neurosci Lett. 2021;751:135746. https://doi.org/10.1016/j.neulet.2021.135746. PMid:33610674.

5. Spoerl D, Nigolian H, Czarnetzki C, Harr T. Reclassifying anaphylaxis to neuromuscular blocking agents based on the presumed pathomechanism: IgE-mediated, pharmacological adverse reaction or “innate hypersensitivity”? Int J Mol Sci. 2017;18(6):1223. https://doi.org/10.3390/ijms18061223. PMid:28590439.

6. Elst J, Maurer M, Sabato V, Faber MA, Bridts CH, Mertens C et al. Novel insights on MRGPRX2-mediated hypersensitivity to neuromuscular blocking agents and fluoroquinolones. Front Immunol. 2021;12:668962. https://doi.org/10.3389/fimmu.2021.668962. PMid:34385999.

7. Jiang W, Hu S, Che D, An H, Liu R. A mast-cell-specific receptor mediates iopamidol-induced immediate IgE-independent anaphylactoid reactions. Int Immunopharmacol. 2019;75:105800. https://doi.org/10.1016/j.intimp.2019.105800. PMid:31401386.

8. Azimi E, Reddy VB, Lerner EA. Brief communication: MRGPRX2, atopic dermatitis and red man syndrome. Itch (Phila). 2017;2(1):e5. https://doi.org/10.1097/itx.0000000000000005. PMid:28367504.

9. Alves Jr WX, Ribeiro M, Aun MV, Giavina-Bianchi P. Determinação da reatividade cutânea às quinolonas e fatores associados. Arq Asma Alerg Imunol. 2023;7(4):367-75. https://doi.org/10.5935/2526-5393.20230055.

10. Hsu FI, Bernstein JA, Chhiba KD, Saini SS. Systemic treatments for chronic spontaneous urticaria: anti-IgE and beyond. J Allergy Clin Immunol Pract. 2026;14(2):361-72. https://doi.org/10.1016/j.jaip.2025.11.038. PMid:41654334.

11. Zarabian N, Farah M, Stines A, Friedman A. Targeting mast cells in chronic spontaneous urticaria. Curr Allergy Asthma Rep. 2026;26(1):9. https://doi.org/10.1007/s11882-025-01245-2. PMid:41697480.


Submitted date:
12/14/2025

Accepted date:
05/24/2026

6a469300a953957f7f593227 aaai Articles
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