Vitamina D e dermatite atópica: o que há de novo?
Vitamin D and atopic dermatitis: what is new?
Renata Robl; Vânia O. Carvalho; Marjorie Uber; Kerstin T. Abagge; Rosana M. Pereira
Resumo
Não há consenso sobre quais são os valores ideais da vitamina D em crianças saudáveis. Porém, níveis séricos altos ou baixos parecem ter influência na fisiopatologia das doenças alérgicas. Há dados na literatura atual que demonstram os potenciais efeitos da vitamina D em aumentar a atividade dos peptídeos antimicrobianos e suprimir a resposta inflamatória, apontando uma relação inversa entre os níveis de vitamina D e a gravidade da dermatite atópica. O objetivo do presente trabalho foi revisar artigos publicados sobre a relação entre níveis séricos de vitamina D e dermatite atópica, uma vez que a vitamina D tem sido implicada em várias ações imunomoduladoras e alguns estudos têm descrito sua influência na gravidade da dermatite atópica, porém com resultados conflitantes. Este estudo baseou-se em revisão de artigos originais, artigos de revisão e consensos publicados nos últimos 10 anos, obtidos a partir da pesquisa dos termos “vitamin D” e “atopic dermatitis”, nos bancos de dados online. Concluímos que a suplementação da vitamina D pode trazer benefícios no tratamento da dermatite atópica. No entanto, mais pesquisas são necessárias para determinar se existe alguma relação entre os níveis de vitamina D e a gravidade da dermatite atópica.
Palavras-chave
Abstract
There is no consensus about optimal values of vitamin D in normal children. However, high or low serum levels seem to influence the pathophysiology of allergic diseases. There is evidence supporting the potential effects of vitamin D on increasing the activity of antimicrobial peptides and suppressing the inflammatory response, indicating an inverse relationship between vitamin D levels and the severity of atopic dermatitis. Our objective was to review published articles on the relationship between serum vitamin D levels and atopic dermatitis, as vitamin D has been implicated in several immunoregulatory actions, and some studies have reported an influence on the severity of atopic dermatitis, with conflicting results. The present study reviewed original articles, review articles, and consensus documents published in the past 10 years, retrieved in online databases using the keywords “vitamin D” and “atopic dermatitis.” We conclude that vitamin D supplementation may be beneficial in the treatment of atopic dermatitis. However, more research is needed to determine whether there is any relationship between vitamin D levels and atopic dermatitis severity.
Keywords
Referências
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Submetido em:
26/10/2013
Aceito em:
09/06/2014
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