Reação de hipersensibilidade a levotiroxina e dessensibilização oral
Hypersensitivity reaction to levothyroxin and oral desensitization
Sérgio Duarte Dortas Junior; Franklin Moreira De Araujo; Cíntia Ribas Souza; Eduardo Micmacher; Soloni Afra Pires Levy; Augusto Tiaqui Abe; Alfeu Tavares França
Resumo
A tiroxina sintética (T4) é o tratamento de escolha para a correção do hipotireoidismo. Reações de hipersensibilidade a levotiroxina são raras. Relatamos um caso de reação maculopapular induzida por levotiroxina, com dessensibilização oral bem sucedida.
Palavras-chave
Abstract
Synthetic thyroxine (T4) is the treatment of choice for the correction of hypothyroidism. Hypersensitivity reactions to levothyroxin are rare. We report a case of maculopapular reaction induced by levothyroxin, with successful oral desensitization.
Keywords
References
1. Almandoz JP, Gharib H. Hypothyroidism: etiology, diagnosis, and management. Med Clin North Am. 2012;96:203-21.
2. Shibata H, Hayakawa H, Hirukawa M, Tadokoro K, Ogata E. Hypersensitivity caused by synthetic thyroid hormones in a hypothyroid patient with Hashimoto's thyroiditis. Arch Intern Med. 1986;146:1624-5.
3. Nugent JS, Nugent AL, Whisman BA, White K, Hagan LL. Levothyroxine anaphylaxis? Vocal cord dysfunction mimicking an anaphylactic drug reaction. Ann Allergy Asthma Immunol. 2003;91:337-41.
4. Kaur S, Bhalla M, Thami GP. Subacute lichenoid eruption due to L-thyroxine overdosage. Dermatology. 2003;206:346-7.
5. Sala A, Labrador-Horrillo M, Guilarte M, Luengo O, Rueda M, Cardona V. Immediate-type hypersensitivity reaction to levothyroxine and desensitization. Ann Allergy Asthma Immunol. 2008;100:513-4.
6. Ksouda K, Affes H, Masmoudi A, Sahnoun Z, Hakim A, Ghozzi H, et al. Levothyroxine induced eczematiform skin eruption and generalized pruritus: a case report. Therapie. 2010;65:587-9.
7. Fevzi D, Mustafa G, Ozgur K, Cetin T, Abdullah B, Sait Y, et al. Successful oral desensitization to levothyroxine. Ann Allergy Asthma Immunol. 2013;111:146-7.
8. Joint Task Force on Practice Parameters; American Academy of Allergy, Asthma and Immunology; American College of Allergy, Asthma and Immunology; Joint Council of Allergy, Asthma and Immunology. Drug allergy: an updated practice parameter. Ann Allergy Asthma Immunol. 2010;105:259-73.
9. Rerkpattanapipat T, Chiriac AM, Demoly P. Drug provocation tests in hypersensitivity drug reactions. Curr Opin Allergy Clin Immunol. 2011;11:299-304.
Submitted date:
11/10/2014
Accepted date:
04/18/2015
