Deficiência do componente C5 do complemento associada a meningites meningocócicas
Complement component C5 deficiency associated with meningococcal meningitis
Wilma C. Neves Forte; Tainá Mosca; Vitor A. P. Mazon; Elias J. E. Ghosn; Raphael J. P. Fins; Carlos A. Longui; Maria da Conceição S. de Menezes
Resumo
O presente estudo teve como objetivo relatar o caso de paciente com infecções meningocócicas graves, avaliar seu sistema complemento e o de 22 membros de sua família. Foram quantificados o complemento total (CH50) e os componentes C3, C4 e C5 do complemento. Foi observado que a paciente e quatro familiares apresentavam deficiência do componente C5: dois haviam apresentado meningites meningocócicas graves e um apresentou a infecção logo após o diagnóstico da deficiência. Concluímos que a paciente com história de infecções meningocócicas graves apresentou deficiência do componente C5 do complemento, assim como quatro de seus familiares. Nossos resultados indicam que a avaliação do sistema complemento em portadores de infecções meningocócicas e em familiares próximos deva ser realizada para identificar pacientes de risco.
Palavras-chave
Abstract
The present study reports the case of a patient with serious meningococcal infections and describes the results of complement system evaluation in the patient and in 22 family members. Total complement activity (CH50) and complement components C3, C4, and C5 were quantified. The patient and four family members showed C5 complement deficiency: two had developed severe meningococcal meningitis and one had the infection soon after the diagnosis of complement deficiency was made. We concluded that our patient with a history of severe meningococcal infections presented complement C5 deficiency, as did four of her family members. These findings indicate that evaluation of the complement system in patients with meningococcal infections and their family members should be performed to identify patients at risk.
Keywords
Referências
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Submetido em:
18/06/2015
Aceito em:
21/11/2015
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