Dermatite autoimune à progesterona
Autoimmune progesterone dermatitis
Danilo Gois Gonçalves; Jorge Kalil; Pedro Giavina-Bianchi
Resumo
A dermatite autoimune à progesterona (DAP) é uma reação autoimune à progesterona de origem endógena ou exógena, caracterizada por manifestações clínicas e mecanismos fisiopatológicos diversos. Doença complexa, subdiagnosticada e associada à alta morbidade. O diagnóstico de DAP baseia-se na associação de sintomas cíclicos ou induzidos por progesterona exógena, testes cutâneos e/ou de provocação à progesterona positivos, e resposta clínica à inibição da ovulação.
Palavras-chave
Abstract
Autoimmune progesterone dermatitis (APD) is an autoimmune reaction to either endogenous or exogenous progesterone, characterized by diverse clinical manifestations and pathophysiological mechanisms. This complex disease is underdiagnosed and associated with high rates of morbidity. The diagnosis of APD is based on the association of cyclical symptoms or symptoms induced by exogenous progesterone, positive skin tests and/or the progesterone challenge test, as well as on clinical response to ovulation inhibition.
Keywords
Referências
1. Özmen İI, Aktürk E. Autoimmune progesterone dermatitis presenting with purpura. Cutis. 2016;98(5):E12-E13.
2. Toms-Whittle LM, John LH, Griffiths DJ, Buckley DA. Autoimmune progesterone dermatitis: a diagnosis easily missed. Clin Exp Dermatol. 2011;36(4):378-80.
3. Nguyen T, Razzaque Ahmed A. Autoimmune progesterone dermatitis: Update and insights. Autoimmun Rev. 2016;15(2):191-7.
4. James T, Ghaferi J, LaFond A. The histopathologic features of autoimmune progesterone dermatitis. J Cutan Pathol. 2017;44(1):70-4.
5. Prieto-Garcia A, Sloane DE, Gargiulo AR, Feldweg AM, Castells M. Autoimmune progesterone dermatitis: clinical presentation and management with progesterone desensitization for successful in vitro fertilization. Fertil Steril. 2011;95(3):1121.e9-13.
6. Kaygusuz I, Gumus II, Sarifakioglu E, Eser A, Bozkurt B, Kafali H. Autoimmune progesterone dermatitis. Taiwan J Obstet Gynecol. 2014;53(3):420-2.
7. Hacinecipo lu F, Benar H, Gönül M, Okçu Heper A. A case of autoimmune progesterone dermatitis characterized by grouped small vesicles. Clin Exp Dermatol. 2016;41(6):681-2.
8. Grunnet KM, Powell KS, Miller IA, Davis LS. Autoimmune progesterone dermatitis manifesting as mucosal erythema multiforme in the setting of HIV infection. JAAD Case Rep. 2017;3(1):22-4.
9. Salman A, Ergun T. Autoimmune progesterone dermatitis mimicking fixed drug eruption. J Dtsch Dermatol Ges. 2017;15(2):219-20.
10. Fournier JB. Resolution of autoimmune progesterone dermatitis after treatment with oral contraceptives. JAAD Case Rep. 2015;1(5):319‑20.
11. Honda T, Kabashima K, Fujii Y, Katoh M, Miyachi Y. Autoimmune progesterone dermatitis that changed its clinical manifestation from anaphylaxis to fixed drug eruption-like erythema. J Dermatol. 2014;41(5):447-8.
12. Camões S, Sampaio J, Rocha J, Tiago P, Lopes C. Autoimmune progesterone dermatitis: case report of an unexpected treatment reaction. Australas J Dermatol. 2017 Aug;58(3):e132-e134.
13. Lahmam Bennani Z, El Fekih N, Baccouche D, Khaled A, Zaglaoui F, Fazaa B. Autoimmune progesterone dermatitis. Ann Dermatol Venereol. 2012;139(12):832-5.
14. Amsler E, Augey F, Soria A, Boccon-Gibod I, Doutre MS, MathelierFusade P, et al. Chronic urticaria and hormones: is there a link? J Eur Acad Dermatol Venereol. 2016;30(9):1527-30.
15. Poffet F, Abraham S, Taramarcaz P, Fontao L, Borradori L. Autoimmune progesterone dermatitis: potential role of cutaneous angiogenin expression? Dermatology. 2011;223(1):32-5.
16. Kim CH. A functional relay from progesterone to vitamin D in the immune system. DNA Cell Biol. 2015;34(6):379-82.
17. Warin AP. Case 2. Diagnosis: erythema multiforme as a presentation of autoimmune progesterone dermatitis. Clin Exp Dermatol. 2001;26(1):107-8.
18. Lee MK, Lee WY, Yong SJ, Shin KC, Lee SN, Lee SJ, et al. A case of autoimmune progesterone dermatitis misdiagnosed as allergic contact dermatitis. Allergy Asthma Immunol Res. 2011;3(2):141-4.
19. Gonçalves DG, Oliveira M, Yonekura C, Pedroso NF, Garro LS, Aun MV, et al. Dermatite autoimune por progesterona (Anais do XLIII Congresso Brasileiro de Alergia e Imunologia, 2016, Curitiba]. Braz J Allergy Immunol. 2016;3(4):190.
20. Le K, Wood G. A case of autoimmune progesterone dermatitis diagnosed by progesterone pessary. Australas J Dermatol. 2011;52(2):139-41.
Submetido em:
03/11/2017
Aceito em:
20/11/2017
Facebook
LinkedIn
Mendeley
StumbleUpon
Reddit
Email