Fatores associados aos sintomas de doenças atópicas em crianças de 6-7 anos em um município da Região Sul do Brasil
Factors associated with the symptoms of atopic diseases in children aged 6-7 years in a municipality in southern Brazil
Julia Carvalho Kozelinski; Karoliny dos-Santos; Bruna Becker da-Silva; Jefferson Traebert; Aline Daiane Schlindwein
Resumo
Introdução: Considerando que os mecanismos pelos quais as doenças atópicas têm aumentado em frequência e gravidade não são inteiramente conhecidos, o presente estudo tem por objetivo analisar os fatores associados aos sintomas das doenças atópicas em crianças de 6-7 anos. Método: Estudo observacional do tipo caso-controle realizado com crianças de 6-7 anos em uma cidade do Sul do Brasil. Questionários foram aplicados às mães das crianças, e os sintomas de doenças atópicas foram triados pelo questionário do International Study of Asthma and Allergy in Childhood (ISAAC). Resultados: Participaram do estudo 255 crianças (85 casos e 170 controles). Os fatores associados às doenças atópicas foram: história familiar de asma (OR: 4,61; IC95% 2,63-0,73), rinite (OR: 3,46; IC95% 1,90-3,26) e eczema (OR: 3,42; IC95% 1,91-6,14), corrimento vaginal na gestação (OR: 4,25; IC95% 2,31-7,84), icterícia neonatal (OR: 2,38; IC95% 1,21-4,68), infecções respiratórias dos tratos superior e inferior (OR: 3,75; IC95% 2,13-3,62; OR: 3,68; IC95% 2,00-6,76, respectivamente), refluxo gastroesofágico (OR: 3,83; IC95% 1,87-7,82), além do tabagismo domiciliar (OR: 2,00; IC95% 1,10-3,64), mofo/umidade no quarto (OR = 3,34; IC95% 1,82-6,12) e animais em casa (OR: 1,77 IC95% 1,04-3,02). Conclusão: Casos de atopia estão associados a história familiar, infecções gestacionais maternas e neonatal, além de variáveis ambientais como o tabagismo e mofo.
Este documento possui uma errata: https://doi.org/10.4322/2526-5393.20200007er
Palavras-chave
Abstract
Introduction: Considering that the mechanisms by which atopic diseases have increased in frequency and severity are not entirely known, the present study aims to analyze the factors associated with symptoms of atopic diseases in children aged 6-7 years. Method: This case-control observational study recruited children aged 6-7 years in a city in southern Brazil. The questionnaires were administered to the children’s mothers and the symptoms of atopic diseases were screened through the International Study of Asthma and Allergy in Childhood (ISAAC) questionnaire. Results: The study included 255 children (85 cases and 170 controls). Factors associated with atopic diseases were family history of asthma (OR: 4.61; 95% CI: 2.63-0.73), rhinitis (OR: 3.46; 95% CI: 1.90- 3.26), eczema (OR: 3.25; 95% CI: 1.91-6.14), vaginal discharge during pregnancy (OR: 4.25; 95% CI: 2.31-7.84), neonatal hyperbilirubinemia (OR: 2.38; 95% CI: 1.21-4.68), upper and lower respiratory infections (OR: 3.75; 95% CI: 2.13-3.62; and OR: 3.68; 95% CI: 2.00-6.76, respectively), gastroesophageal reflux (OR: 3.83; 95% CI: 1.87-7.82), in addition to household smoking (OR: 2.00; 95% CI: 1.10-3.64), mold in the bedroom (OR: 3.34; 95% CI: 1.82-6.12) and pets at home (OR: 1.77; 95% CI: 1.04-3.02). Conclusion: Cases of atopic diseases are associated with family history, maternal and neonatal infections, and environmental exposures such as smoking and mold.
This document has an erratum: https://doi.org/10.4322/2526-5393.20200007er
Keywords
Referências
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Submetido em:
10/02/2020
Aceito em:
14/03/2020
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