Chronic spontaneous urticaria:
correlation of basophil counts with disease control
and response to anti-IgE therapy

Helena Pereira; João Lopes; Isabel Carrapatoso; Ana Todo-Bom

doi:10.5935/2526-5393.20230087

Clinical and Experimental Communication

Chronic spontaneous urticaria: correlation of basophil counts with disease control and response to anti-IgE therapy

Urticária crônica espontânea: correlação dos valores de basófilos com o controle da doença e a resposta à terapêutica anti-IgE

Helena Pereira; João Lopes; Isabel Carrapatoso; Ana Todo-Bom

http://dx.doi.org/10.5935/2526-5393.20230087 Arq Asma Alerg Imunol, vol.8, n2, p.146-150, 2024

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Abstract

This retrospective study aimed to investigate the relationship between peripheral blood basophil counts and response to treatment with omalizumab in patients with chronic spontaneous urticaria (CSU). Most patients included in the study had a normal basophil count, but a significant correlation was found between a low basophil count and daily use of antihistamines still required to control symptoms. This suggests the potential utility of basophil count as a prognostic marker of response to anti-IgE monoclonal antibody therapy in CSU.

Keywords

Urticaria, basophils, biomarkers, omalizumab.

Resumo

Este estudo retrospectivo procurou investigar a relação entre os níveis de basófilos periféricos em doentes com urticária crônica espontânea (UCE) em tratamento com omalizumab e a sua resposta terapêutica. Dos pacientes incluídos, a maioria apresentou níveis normais de basófilos, mas uma correlação significativa foi encontrada entre valores baixos de basófilos e o uso diário de anti-histamínicos ainda necessários para controle sintomático, colocando a hipótese da potencial utilidade destes como marcador prognóstico na UCE na resposta à terapêutica monoclonal anti-IgE.

Palavras-chave

Urticária, basófilos, biomarcadores, omalizumab.

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Submitted date:
05/06/2024

Accepted date:
06/30/2024