Arquivos de Asma, Alergia e Imunologia
https://www.aaai-asbai.org.br/article/doi/10.5935/2526-5393.20240041-en
Arquivos de Asma, Alergia e Imunologia
Clinical and Experimental Communication

Recurrent sepsis in secondary immunodeficiency induced by nasal steroid misuse

Sepse de repetição na imunodeficiência secundária por uso abusivo de corticoide nasal

Bruna Giavina-Bianchi; Adriana Pitchon; André Luiz Oliveira Feodrippe; Pedro Giavina-Bianchi

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Abstract

Nasal corticosteroids are recommended as first-line therapy for patients with moderate-to-severe allergic rhinitis. We report a case of a patient who presented with recurrent sepsis and was found to have secondary immunodeficiency induced by inappropriate use of nasal corticosteroids, highlighting the risks associated with the misuse of this medication.

Keywords

Secondary immunodeficiency, nasal steroids, septicemia, Cushing’s syndrome, corticosteroids.   

Resumo

Recomenda-se o uso de corticoides nasais como tratamento de primeira linha na rinite alérgica moderada a grave. Relatamos o caso clínico de um paciente com sepse de repetição no contexto de imunodeficiência secundária ao uso inapropriado de corticoide nasal, destacando-se os riscos associados ao uso abusivo de tais medicamentos.

Palavras-chave

Imunodeficiência secundária, corticoides nasais, septicemia, síndrome de Cushing, corticosteroides. 

References

1. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-10.

2. Cain DW, Cidlowski JA. Immune regulation by glucocorticoids. Nat Rev Immunol. 2017;17(4):233-47.

3. Gurnell M, Heaney LG, Price D, Menzies-Gow A. Long-term corticosteroid use, adrenal insufficiency, and the need for steroid-sparing treatment in adult severe asthma. J Intern Med. 2021;290(2):240-56.

4. Giavina-Bianchi P, Aun MV, Takejima P, Kalil J, Agondi RC. United airway disease: current perspectives. J Asthma Allergy. 2016 May 11;9:93-100.

5. Fuchs M, Wetzig H, Kertscher F, Täschner R, Keller E. Iatrogenic Cushing syndrome and mutatio tarda caused by dexamethasone containing nose drops. HNO. 1999;47(7):647-50.


Submitted date:
11/07/2024

Accepted date:
11/14/2024

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